Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,676 – 3,690 of 4,595 results

3,676

Medchemexpress LLC TCO-SS-amine | >=95.0% | 304.47 | C13H24N2O2S2 | 5 MG

TCO-SS-amine is a cleavable antibody-drug conjugate (ADC) linker containing a trans-cyclooctene (TCO) group that enables inverse electron demand Diels-Alder (iEDDA) click reactions with tetrazine-functionalized partners. It is used as a disulfide-cleavable linker in ADC synthesis and as a bioorthogonal click chemistry reagent.

Cleavable disulfide linker for ADC synthesis.
Contains a TCO group for iEDDA click chemistry with tetrazines.
Molecular formula: C13H24N2O2S2.
Molecular weight: 304.47 g/mol.
Purity: ≥95.0%.
Storage: -20°C, protect from light; in solvent: -80°C up to 6 months.
Available in small research pack sizes such as 5 mg.

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3,677

Medchemexpress LLC Spdb | 115088-06-7 | MFCD20229028 | 98.0% | 326.40 g·mol⁻¹ | C13H14N2O4S2 | 200 MG

SPDB is a glutathione-cleavable antibody-drug conjugate (ADC) linker provided for research use. It is designed to remain stable in circulation and be cleaved intracellularly by glutathione to release payloads, making it suitable for ADC synthesis, conjugation method development, and linker-cleavage studies.

Glutathione-cleavable linker
Stable in circulation, labile in target cells
Suitable for ADC synthesis and linker-cleavage studies
High purity (~98.0%) for reproducible results
Available in multiple package sizes, including 200 mg
Store sealed, away from moisture; recommended -20°C

Pricing & Availability

3,678

eMolecules 4965-36-0 | 7-Bromoquinoline | Oakwood Chemical | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 5g | 537699226

7-Bromoquinoline | Oakwood Chemical | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 5g | 537699226

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3,679

eMolecules 4965-36-0 | 7-Bromoquinoline | Oakwood Chemical | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 25g | 537699227

7-Bromoquinoline | Oakwood Chemical | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 25g | 537699227

Pricing & Availability

3,680

eMolecules 4965-36-0 | 7-Bromoquinoline | Oakwood Chemical | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 100g | 537699228

7-Bromoquinoline | Oakwood Chemical | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 97.000 | Brc1ccc2cccnc2c1 | 100g | 537699228

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3,681

Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG

Navitoclax (ABT-263) is a potent, orally active small-molecule inhibitor of anti-apoptotic Bcl-2 family proteins used in preclinical apoptosis and oncology research. Supplied as a powder, it is used for both in vitro assays and in vivo models, with documented solubility and recommended storage for stability.

Potent Bcl-2 family inhibitor for apoptosis research.
Orally active small molecule suitable for in vivo studies.
High solubility in DMSO for convenient stock solutions.
Available in multiple quantities for dosing flexibility.
Recommended storage conditions to preserve stability.

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3,682

Medchemexpress LLC RGW-611 50mg | 6497-78-5 | 50MG

RGW 611 is a morpholine derivative that enhances radiation-induced cell death of hypoxic V79-379A cells RGW 611 also stimulates fatty acid synthesis[1 [2

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3,683

Apexbio Technology LLC BMS-626529 701213-36-7 200mg

BMS-626529 is a small molecule inhibitor designed to block HIV-1 attachment to host cells Its mechanism involves binding to the viral envelope protein gp120 thereby hindering gp120-mediated interactions with CD4 receptors on CD4 T cells and preventing initial viral entry In cell-based assays BMS-626529 shows strain-specific antiviral activity with IC50 values mostly below 10 nM and notably low picomolar IC50 against highly susceptible HIV-1 isolates This molecule serves as a research tool to investigate HIV-1 entry inhibition and virus-host interaction mechanisms in biomedical studies

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3,684

Apexbio Technology LLC MHY1485 326914-06-1 200mg

MHY1485 (CAS 326914-06-1) is a potent activator of mammalian target of rapamycin (mTOR) a serine/threonine kinase critical for cellular growth metabolism and survival pathways By activating mTOR signaling MHY1485 inhibits autophagy initiation and disrupts the fusion step between autophagosomes and lysosomes resulting in accumulation of autophagic marker LC3-II and enlarged autophagic structures In cultured rat Ac2F hepatic cells MHY1485 suppresses basal and starvation-induced autophagic flux Additionally MHY1485 treatment promotes ovarian follicular development and increases explant growth in mouse ovarian culture models providing a useful tool in biomedical research of mTOR signaling and reproductive biology

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3,685

Chem-Impex International, Inc. CHEM IMPEX INTL INC

NC4029543 7-AZABENZOTRIAZOL-1 25G

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3,686

Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 200mg

Regorafenib monohydrate (CAS 1019206-88-2) is a multitargeted tyrosine kinase inhibitor that suppresses numerous intracellular and membrane receptor tyrosine kinases (RTKs) including VEGFR (types 1-3) PDGFR- FGFR-1 RET TIE2 c-KIT Raf-1 and BRAF (wild-type and V600E mutant) It inhibits angiogenic RTKs such as VEGFR-2 with IC50 values ranging from approximately 4 2 to 46 nM and oncogenic RTKs like c-KIT and RET with IC50 values around 1 5 to 28 nM Regorafenib demonstrates antiproliferative activity in vitro (mean IC50 1 M) and reduces tumor progression in xenograft animal models supporting its use in cancer research involving breast colorectal thyroid pancreatic cancers melanoma and gastrointestinal stromal tumors

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3,687

Apexbio Technology LLC LKB1 (AAK1 dual inhibitor) 1093222-27-5 200mg

LKB1 (AAK1 dual inhibitor CAS 1093222-27-5) is a selective inhibitor targeting both LKB1 kinase and adaptor-associated kinase 1 (AAK1) These kinases are serine/threonine protein kinases implicated in cellular metabolism polarity and endocytic trafficking pathways respectively By simultaneously inhibiting LKB1 and AAK1 activity this small molecule modulates diverse intracellular signaling cascades associated with cell proliferation and membrane trafficking Due to these mechanistic features LKB1 (AAK1 dual inhibitor) serves as a valuable research tool for studying kinase-associated pathways in various biomedical contexts and potentially informing therapeutic strategies

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3,688

eMolecules 8-CHLORONAPHTHALEN-1-AMINE 5G

5000188155 8-CHLORONAPHTHALEN-1-AMINE 5G

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3,689

Apexbio Technology LLC SCH 527123 473727-83-2 200mg

SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth

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3,690

eMolecules 7681-84-7 | Tetrahydrofuran-2-carbaldehyde, 50% in toluene | Combi-Blocks, Inc. | MFCD01726184 | 100.117 | C5H8O2 | 90.000 | O=CC1CCCO1 | 100mg | 882681099

Tetrahydrofuran-2-carbaldehyde, 50% in toluene | Combi-Blocks, Inc. | 7681-84-7 | MFCD01726184 | 100.117 | C5H8O2 | 90.000 | O=CC1CCCO1 | 100mg | 882681099

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Quinolines and derivatives

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Medchemexpress LLC TCO-SS-amine | >=95.0% | 304.47 | C13H24N2O2S2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Spdb | 115088-06-7 | MFCD20229028 | 98.0% | 326.40 g·mol⁻¹ | C13H14N2O4S2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Navitoclax (ABT-263) | 923564-51-6 | MFCD12756219 | ≥98.0% | 974.61 g·mol⁻¹ | C47H55ClF3N5O6S3 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC RGW-611 50mg | 6497-78-5 | 50MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC BMS-626529 701213-36-7 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC MHY1485 326914-06-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Regorafenib monohydrate 1019206-88-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC LKB1 (AAK1 dual inhibitor) 1093222-27-5 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC SCH 527123 473727-83-2 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More